Author

E. S. Giotis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Assay:bulk RNA-seq· 7 Research Focus:host-pathogen & immune response· 7 Organism:chicken / avian· 5 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:E. coli· 1

Frequent Co-Authors

M. A. Skinner· 6 shared A. J. Broadbent· 3 shared K. L. Dulwich· 3 shared N. J. Temperton· 2 shared W. S. Barclay· 2 shared A. Banyard· 1 shared A. G. Gray· 1 shared A. Gray· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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6 shared papersMicrobiology

M. A. Skinner

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The antiviral potential of the antiandrogen enzalutamide and the viral-androgen interplay in seasonal coronaviruses

O. D. Ogunjinmi, T. Abdullahi, R.-A. Somji, C. L. Bevan, W. S. Barclay, N. J. Temperton, G. N. Brooke, E. S. Giotis

This study investigates enzalutamide's antiviral effects against seasonal coronaviruses and identifies differences in viral-androgen signaling interactions between HCoV-229E and HCoV-OC43.

bioRxiv · Nov 25, 2023 · PreprintMicrobiology

Serological evidence of high pathogenicity virus infection in Eidolon helvum fruit bats in Nigeria

D. Cantoni, M. Mayora Neto, B. Auld, K. Da Costa, J. Del Rosario, V. O. Ameh, C. T. Sabeta, M. Derveni, A. Hamlet, E. Wright, S. Scott, E. S. Giotis, A. Banyard, N. J. Temperton

The study detects neutralizing antibodies against henipavirus, Nipah virus, and bat influenza in Eidolon helvum bats in Nigeria, suggesting a potential zoonotic spillover risk.

bioRxiv · Jun 14, 2023 · PreprintMicrobiology

Primary human macrophages exhibit a modest inflammatory response early in SARS-CoV-2 infection

Z. Zhang, R. Penn, W. S. S. Barclay, E. S. Giotis

This study shows that primary human macrophages do not support SARS-CoV-2 replication and exhibit a limited cytokine response, unlike influenza viruses which induce strong IFN-β and proinflammatory cytokines.

bioRxiv · Feb 2, 2022 · PreprintMicrobiology

Transcriptomic analysis reveals that severity of infectious bursal disease in White Leghorn inbred chicken lines is associated with greater bursal inflammation in vivo and more rapid induction of pro-inflammatory responses in primary bursal cells stimulated ex vivo.

A. S. Asfor, S. Nazki, V. R. Reddy, E. Campbell, K. L. Dulwich, E. S. Giotis, M. A. Skinner, A. J. Broadbent

This study compares the transcriptomic responses of inbred chicken lines to IBDV infection, finding that severe disease correlates with enhanced inflammation and faster pro-inflammatory gene induction in bursal cells.

bioRxiv · Mar 18, 2021Microbiology

Modulation of early host innate immune response by a Fowlpox virus (FWPV) lateral body protein

E. S. Giotis, S. M. Laidlaw, S. R. Bidgood, D. Albrecht, J. J. Burden, R. C. Robey, J. Mercer, M. A. Skinner

This study identifies FPV184 as a Fowlpox virus protein that suppresses host IFN responses by inhibiting promoter activation and localizing to viral lateral bodies.

bioRxiv · Oct 2, 2020Microbiology

Chicken cGAS senses fowlpox virus infection and regulates macrophage effector function

M. Oliveira, D. R. Rodrigues, V. Guillory, E. Kut, E. S. Giotis, M. A. Skinner, R. Guabiraba, C. E. Bryant, B. J. Ferguson

This study shows that chicken cGAS detects fowlpox virus DNA, triggering type-I interferon production and regulating macrophage effector functions like MHC-II expression.

bioRxiv · Oct 1, 2020Immunology

The stronger downregulation of in vitro and in vivo innate antiviral responses by a very virulent strain of infectious bursal disease virus (IBDV), compared to a classical strain, is mediated, in part, by the VP4 protein.

K. L. Dulwich, A. S. S. Asfor, A. G. Gray, E. S. Giotis, M. A. Skinner, A. J. Broadbent

This study compares the innate antiviral responses of two IBDV strains, showing that the very virulent UK661 strain suppresses IFN and proinflammatory gene expression more than the classical F52/70 strain, mediated in part by the VP4 protein.

bioRxiv · Dec 17, 2019Microbiology

The MHC class-II HLA-DR receptor mediates bat influenza A-like H17N10 virus entry into mammalian cells

E. S. Giotis, G. Carnell, E. F. Young, S. Ghanny, P. Soteropoulos, W. S. Barclay, M. A. Skinner, N. Temperton

This study identifies HLA-DR as a receptor for bat influenza A-like H17N10 virus entry into mammalian cells, revealing a novel mechanism distinct from classical influenza A viruses.

bioRxiv · Jan 4, 2019Microbiology

Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV)

K. L. Dulwich, E. S. Giotis, A. Gray, V. Nair, M. A. Skinner, A. J. Broadbent

This study compares gene expression in chicken B cells infected with attenuated and very virulent IBDV strains to identify differences in immune response and virulence factors.

bioRxiv · Aug 24, 2017Microbiology