Cancer BiologybioRxivPreprint
Orthogonal targeting of KDM6A/B and HDACs mediates potent therapeutic effects in IDH1-mutant glioma
A. Kayabolen, E. Yilmaz, G. N. Sahin…·T. Bagci-Onder
This study identifies GSK-J4 and Belinostat as effective therapies for IDH1-mutant glioma by targeting KDM6A/B and HDACs, showing synergistic effects in vitro and in vivo.