Author

A. P. Cribbs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 5 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

M. Philpott· 4 shared A. Cingoz· 2 shared F. Seker-Polat· 2 shared J. Y. Mimpen· 2 shared M. J. Baldwin· 2 shared S. J. B. Snelling· 2 shared T. Bagci-Onder· 2 shared U. Oppermann· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersImmunology

M. Philpott

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Single nucleus and spatial transcriptomic profiling of human healthy hamstring tendon

J. Y. Mimpen, L. D. Ramos-Mucci, C. Paul, A. Kurjan, P. Hulley, C. Ikwuanusi, S. Gwilym, M. J. Baldwin, A. P. Cribbs, S. J. B. Snelling

This study profiles the transcriptome and spatial distribution of cell types in healthy human hamstring tendon using snRNA-seq and spatial transcriptomics, identifying 12 cell types and highlighting fibroblasts' role in tissue homeostasis.

bioRxiv · Dec 19, 2022Cell Biology

Epigenetic-focused CRISPR/Cas9 screen identifies ASH2L as a regulator of glioblastoma cell survival

E. Ozyerli-Goknar, E. Y. Kala, A. C. Aksu, I. Bulut, A. Cingoz, S. Nizamuddin, M. Biniossek, F. Seker-Polat, T. Morova, C. Aztekin, S. H. A. Kung, H. Syed, N. Tuncbag, M. Gonen, M. Philpott, , T. Bagci-Onder

This study uses CRISPR/Cas9 screens to identify ASH2L as a key regulator of glioblastoma cell survival, with downstream effects on cell cycle and apoptosis.

bioRxiv · Aug 17, 2022 · PreprintCancer Biology

The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection

D. R. Sandoval, T. Mandel Clausen, C. Nora, J. A. Magida, A. P. Cribbs, A. Denardo, A. E. Clark, A. F. Garretson, J. K. C. Coker, A. Narayanan, S. A. Majowicz, M. Philpott, C. Johansson, J. E. Dunford, C. B. Spliid, , Mazitsch

This study identifies halofuginone as a potent inhibitor of SARS-CoV-2 infection and replication by reducing heparan sulfate biosynthesis and suppressing viral replication.

bioRxiv · Mar 22, 2021 · PreprintMicrobiology

Interleukin-17A causes osteoarthritis-like transcriptional changes in human osteoarthritis-derived chondrocytes and synovial fibroblasts in vitro

J. Y. Mimpen, M. J. Baldwin, A. P. Cribbs, M. Philpott, A. J. Carr, S. G. Dakin, S. J. B. Snelling

This study shows IL-17A induces OA-like gene expression in OA-derived chondrocytes and synovial fibroblasts, with secukinumab inhibiting these effects.

bioRxiv · Mar 5, 2021Immunology

Loss of mutually protective effects between osteoclasts and chondrocytes in damaged joints drives osteoclast-mediated cartilage degradation via matrix metalloproteinases

Q. C. Larrouture, A. P. Cribbs, S. J. Snelling, H. J. Knowles

This study shows that osteoclasts degrade cartilage via MMPs, and their protective interaction with chondrocytes is lost in damaged joints.

bioRxiv · Jan 3, 2021 · PreprintCell Biology

Orthogonal targeting of KDM6A/B and HDACs mediates potent therapeutic effects in IDH1-mutant glioma

A. Kayabolen, E. Yilmaz, G. N. Sahin, F. Seker-Polat, A. Cingoz, B. Isik, S. Acar, S. Karahuseyinoglu, H. Wakimoto, D. P. Cahill, I. Solaroglu, A. P. Cribbs, U. Oppermann, T. Bagci-Onder

This study identifies GSK-J4 and Belinostat as effective therapies for IDH1-mutant glioma by targeting KDM6A/B and HDACs, showing synergistic effects in vitro and in vivo.

bioRxiv · Nov 26, 2020 · PreprintCancer Biology

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

A. P. Cribbs, S. Terlecki-Zaniewicz, M. Philpott, J. Baardman, D. Ahern, M. Lindow, S. Obad, H. Oerum, B. Sampey, P. Mander, H. Penn, P. Wordsworth, P. Bowness, R. K. Prinjha, M. de Winther, , U. Oppermann

This study identifies KDM6A and KDM6B as regulators of human Th17 cell development and effector functions by affecting metabolism and cytokine production.

bioRxiv · Oct 30, 2019Immunology

Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

A. Miar, E. Arnaiz, E. Bridges, S. Beedie, A. P. Cribbs, D. J. Downes, R. Beagrie, J. Rehwinkel, A. L. Harris

This study shows hypoxia reduces type I IFN pathway activity in cancer cells through transcriptional and chromatin changes, independent of HIF1/2.

bioRxiv · Jul 25, 2019Cancer Biology