Endothelial Rap1B mediates T-cell exclusion to promote tumor growth -a novel mechanism underlying vascular immunosuppression
G. P. Sharma, R. Kosuru, S. Lakshmikanthan, S. Zheng, Y. Chen, R. Burns, G. Xin, W. Cui, M. Chrzanowska
This study identifies EC Rap1B as a key mediator of vascular immunosuppression by promoting T-cell exclusion and tumor growth through regulation of CAMs and NFκB signaling.
bioRxiv · Nov 3, 2021Cancer Biology