S. Zheng

Dual-targeted nanoparticulate drug delivery systems for enhancing triple-negative breast cancer treatment

This paper develops a dual-targeted nanoparticulate drug delivery system (SJNP) combining SN38 and JQ-1 to enhance triple-negative breast cancer treatment by disrupting DNA repair and mitochondrial function.

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.

Implementation of pupylation-based proximity labelling in plant biology reveals regulatory factors in cellulose biosynthesis

The paper introduces PUP-IT, a pupylation-based proximity labelling method for detecting protein interactions in plants, and identifies BEN1 as a regulator of cellulose synthesis.

CDC20 determines the sensitivity to spindle assembly checkpoint (SAC) inhibitors

The paper identifies CDC20 expression as a determinant of sensitivity to SAC inhibitors, showing that aneuploid cells with high CDC20 levels are more sensitive to these drugs.

An ancient transcription activator is required for the multiciliogenesis program

This study identifies Edf1 as an essential transcription activator for multiciliogenesis, showing its role in ciliary gene expression and its impact on hydrocephalus in mice.

Filter-aided expansion proteomics

The paper introduces FAXP, a method combining hydrogel expansion and mass spectrometry for high-resolution proteomics of FFPE tissues, showing improved resolution and efficiency over existing methods.

Hybrid Adipocyte-Derived Exosome Nano Platform for Potent Chemo-Phototherapy in Targeted Hepatocellular Carcinoma

This paper develops a hybrid adipocyte-derived exosome platform for targeted chemo-phototherapy of hepatocellular carcinoma, showing enhanced drug delivery and tumor growth inhibition.

SANTA FE OXA: Self-assembled oxaliplatin nanomicelle for enhanced cascade cancer chemotherapy via self-sensitized ferroptosis

This paper develops a nanomicelle, SANTA FE OXA, that enhances cancer chemotherapy by inducing ferroptosis and reducing systemic toxicity.

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase transition potential

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke

This study maps residual mechanical stresses in murine brains across age and after hemorrhagic stroke, finding increased stresses with age and reduced stresses post-stroke.

Longevity Bottlenecks

This paper surveys experts in longevity to identify key bottlenecks and solutions, finding that data sharing and regulatory clarity are critical for advancing aging research.

A Bright, Photostable Dye that Enables Multicolor, Time Lapse, and Super-Resolution Imaging of Acidic Organelles

This paper introduces a far-red dye that selectively labels acidic organelles in live cells, enabling multicolor, time-lapse, and super-resolution imaging with improved photostability and compatibility with long-term experiments.

Chromatin attachment to the nuclear matrix represses hypocotyl elongation in Arabidopsis thaliana

This study shows that the nuclear matrix binding protein AHL22, along with FRS7 and FRS12, represses hypocotyl elongation in Arabidopsis by suppressing SAUR gene expression through chromatin attachment and histone deacetylation.

The curious case of cyanobacteria: a tale of light and darkness

This study shows virus infection increases toxin production in cyanobacteria and reveals their potential as a source of antiviral compounds.

Lipid-anchored Proteasomes Control Membrane Protein Homeostasis

This study identifies N-myristoylation of Rpt2 as a mechanism for proteasome-membrane interaction, showing its role in membrane protein homeostasis and its impact on cellular processes and tumor growth.

CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels

The paper identifies CYP4F2 as a human-specific genetic determinant of plasma N-acyl amino acid levels and shows its role in metabolic diversification.

N-MYC regulates Cell Survival via eIF4G1 in inv(16) Acute Myeloid Leukemia

The paper shows N-MYC promotes survival in inv(16) AML by regulating eIF4G1, identifying a novel MYCN enhancer and a new oncogenic role for eIF4G1 in AML.

Alternative splicing of its 5'-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

This study identifies alternative splicing of CD20 mRNA that generates translation-deficient isoforms, contributing to resistance to CD20-directed immunotherapies.

An ULK1/2-PXN mechanotransduction complex suppresses breast cancer cell migration

This study identifies ULK1/2 as regulators of PXN-dependent mechanotransduction in breast cancer cells, showing their role in inhibiting migration by modulating focal adhesion assembly.

Exosomes derived from BMSCs with miR-124-3p inhibitor protects against LPS-induced endometritis through regulation of DUSP6, p-p65 and p-ERK

This study shows that exosomes from BMSCs with miR-124-3p inhibitor reduce LPS-induced endometritis by modulating DUSP6, p-p65, and p-ERK.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

Spatio-temporal transcriptomic analysis reveals distinct nephrotoxicity, DNA damage and regeneration response after cisplatin

This study uses spatial transcriptomics to analyze cisplatin-induced nephrotoxicity and regeneration in different kidney segments, identifying distinct molecular responses and biomarkers.

PXN/Paxillin Phase Separation Promotes Focal Adhesion Assembly and Integrin Signaling

This study shows that PXN phase separation drives focal adhesion assembly and integrin signaling through light-inducible manipulation.

Boosting wheat functional genomics via indexed EMS mutant library of KN9204

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

A long-acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese non-human primate model

This paper develops a long-acting GDF15 analog that reduces food intake and body weight in obese monkeys, with potential for clinical obesity treatment.

Crystal ribcage: a platform for probing real-time lung function at cellular resolution in health and disease

This paper introduces a transparent ribcage for real-time, cellular-resolution imaging of lung function in health and disease, revealing insights into tumor progression, immune responses, and disease remodeling.

Chromosome-level genome assembly of Torreya grandis provides insights into the origin and evolution of gymnosperm-specific sciadonic acid biosynthesis

The paper presents a chromosome-level genome assembly of T. grandis and identifies genes responsible for gymnosperm-specific sciadonic acid biosynthesis.

Long-term, super-resolution HIDE imaging of the inner mitochondrial membrane in live cells with a cell-permeant lipid probe

Disentangling the complex gene interaction networks between rice and the blast fungus identifies a new pathogen effector

Tracing back primed resistance in cancer via sister cells

The paper introduces ReSisTrace, a method to identify pre-resistant cell states in cancer by analyzing sister cells, and validates its use in ovarian cancer models.