Author

R. Burns

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Evolutionary Biology· 2 Immunology· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Organism:Arabidopsis· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

P. Y. Novikova· 2 shared S. Zheng· 2 shared A. C. Clarke· 1 shared A. D. Scott· 1 shared A. DeMichele· 1 shared A. Hall· 1 shared A. Khan· 1 shared A. M. Storniolo· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPlant Biology

P. Y. Novikova

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Author profile →

8 papers

Recent·Most cited

N-MYC regulates Cell Survival via eIF4G1 in inv(16) Acute Myeloid Leukemia

P. S. Peramangalam, S. Surapally, S. Zheng, R. Burns, N. Zhu, S. Rao, C. Muller-Tidow, J. A. Pulikkan

The paper shows N-MYC promotes survival in inv(16) AML by regulating eIF4G1, identifying a novel MYCN enhancer and a new oncogenic role for eIF4G1 in AML.

bioRxiv · Mar 3, 2023Cancer Biology

Transition to self-compatibility associated with dominant S-allele in a diploid Siberian progenitor of allotetraploid Arabidopsis kamchatica revealed by Arabidopsis lyrata genomes

U. Kolesnikova, A. D. Scott, J. D. Van de Velde, R. Burns, N. P. Tikhomirov, U. Pfordt, A. C. Clarke, L. Yant, A. P. Seregin, X. Vekemans, S. Laurent, P. Y. Novikova

The paper traces the evolution of self-compatibility in diploid Arabidopsis lyrata and its role in the formation of allotetraploid A. kamchatica through genome analysis.

bioRxiv · Jun 24, 2022 · PreprintPlant Biology

Endothelial Rap1B mediates T-cell exclusion to promote tumor growth -a novel mechanism underlying vascular immunosuppression

G. P. Sharma, R. Kosuru, S. Lakshmikanthan, S. Zheng, Y. Chen, R. Burns, G. Xin, W. Cui, M. Chrzanowska

This study identifies EC Rap1B as a key mediator of vascular immunosuppression by promoting T-cell exclusion and tumor growth through regulation of CAMs and NFκB signaling.

bioRxiv · Nov 3, 2021Cancer Biology

Individual-based modeling of genome evolution in haplodiploid organisms

R. Pracana, R. Burns, R. L. Hammond, B. C. Haller, Y. Wurm

The paper develops an individual-based simulation model for haplodiploid species to study genetic evolution and finds that selection is more effective in these species than in diploids.

bioRxiv · Oct 25, 2021Evolutionary Biology

Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Proteinco-immunization in rhesus macaques

M. Rosati, M. Agarwal, X. Hu, S. Devasundaram, D. Stellas, B. Chowdhury, J. Bear, R. Burns, D. Donohue, L. Pessaint, H. Andersen, M. G. Lewis, E. Terpos, M. A. Dimopoulos, A. Wlodawer, , B. K. Felber

This study compares DNA and DNA+protein vaccines in rhesus macaques, finding that co-immunization with both induces stronger antibody responses and better control of SARS-CoV-2 infection.

PLOS Pathogens · Sep 22, 2021Peer-reviewedImmunology

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

S. H. Strand, B. Rivero-Gutierrez, K. E. Houlahan, J. A. Seoane, L. M. King, T. Risom, L. A. Simpson, S. Vennam, A. Khan, L. Cisneros, T. Hardman, B. Harmon, F. Couch, K. Gallagher, M. Kilgore, , K Owzar

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

bioRxiv · Jun 16, 2021 · PreprintCancer Biology

Gradual evolution of allopolyploidy in Arabidopsis suecica

R. Burns, T. Mandakova, J. Jagoda, L. M. Soto-Jimenez, C. Liu, M. A. Lysak, P. Y. Novikova, M. Nordborg

This study examines polyploidization in Arabidopsis suecica, finding no genome shock but evidence of gradual adaptation through subgenome-specific gene upregulation.

bioRxiv · Aug 24, 2020Evolutionary Biology

Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and - independent phagosomal signals that contribute to phagocytosis and inflammation

S. J. Benjamin, K. L. Hawley, M. P. Vera-Licona, C. J. LaVake, J. L. Cervantes, R. Burns, O. Luo, Y. Ruan, M. Caimano, J. D. Radolf, J. C. Salazar

This study investigates MyD88-dependent and -independent phagosomal signaling in macrophages during Borrelia burgdorferi infection, showing their roles in phagocytosis and inflammation.

bioRxiv · Mar 30, 2019 · PreprintImmunology