G. P. Wagner

Experimental and Phylogenetic Evidence for Correlated Gene Expression Evolution between Dermal and Endometrial Fibroblasts: implications for the evolution of cancer malignancy

The paper investigates correlated gene expression evolution between dermal and endometrial fibroblasts across species and in an experimental model, finding significant correlations that support evolutionary links to cancer malignancy.

The extension of mammalian pregnancy required taming inflammation; independent evolution of extended placentation in the tammar wallaby

This paper shows that moderation of inflammation after embryo attachment allows extended placentation in mammals, with evidence from tammar wallabies.

Mapping the Promiscuous Binding Interface of HOX-A11 with KIX by Experimentally Guided in-silico docking

The paper identifies a promiscuous binding motif in HOXA11 IDR that interacts with two sites on the KIX domain of CBP through computational docking guided by experimental data.

Transcriptomic responses to hypoxia in endometrial and decidual stromal cells

This study examines how hypoxia affects gene expression in endometrial and decidual stromal cells, identifying transcriptional changes linked to endometriosis.

The Evolution of Placental Invasion and Cancer Metastasis are Causally Linked

The paper links placental invasion and cancer metastasis by showing that human stromal cells are more permissive to invasion than bovine cells, supporting the Evolved Levels of Invasibility hypothesis.

Evolution of embryo implantation was enabled by the origin of decidual cells in eutherian mammals

This study identifies the evolutionary mechanism by which decidual cells in eutherian mammals suppressed IL17A signaling to enable embryo implantation.

The mammalian decidual cell evolved from a cellular stress response

The paper shows that decidual stromal cells evolved from rewiring an ancestral cellular stress response in opossum endometrial stromal fibroblasts.