T. Hoang

Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10

This study shows that inhibiting PAK2 in endothelial cells reduces tumor angiogenesis and enhances immune cell infiltration via CXCL10 secretion.

An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant viral replication in rhesus macaques

An intranasal SARS-CoV-2 beta variant subunit booster vaccine induced protective immunity against beta variant infection in rhesus macaques one year after initial vaccination.

Validation of a Single-step, Single-tube Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Rapid Detection of SARS-CoV-2 RNA

The paper validates a single-step, single-tube RT-LAMP assay for rapid SARS-CoV-2 detection with high specificity and sensitivity.

An In Vitro Vascularized Micro-Tumor Model of Human Colorectal Cancer Recapitulates In Vivo Drug Responses

This paper validates a vascularized micro-tumor model for colorectal cancer that better replicates in vivo drug responses than traditional 2D or 3D models.

Therapeutically Exploring Persister Metabolism In Bacteria

The paper identifies metabolic inhibitors that reduce bacterial persistence in Escherichia coli and Pseudomonas aeruginosa by targeting redox activities and intracellular degradation.

The Evolution of Placental Invasion and Cancer Metastasis are Causally Linked

The paper links placental invasion and cancer metastasis by showing that human stromal cells are more permissive to invasion than bovine cells, supporting the Evolved Levels of Invasibility hypothesis.

Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases

This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.

Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma

This study compares continuous and bolus intraventricular topotecan in a mouse model of leptomeningeal medulloblastoma, finding both methods improve survival compared to systemic therapy.