Extracellular Vesicles Hijack the Autophagic Pathway to Induce Tau Accumulation in Endolysosomes
G. Pedrioli, M. Barberis, M. Molinari, D. Morone, S. Papin, P. Paganetti
This study shows extracellular vesicles deliver Tau seeds to endolysosomes, where autophagy promotes Tau accumulation and cytotoxicity, suggesting autophagy stimulation may worsen tauopathies.
bioRxiv · May 27, 2020 · PreprintCell Biology