The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation
T. Eisemann, F. Allen, K. Lau, G. R. Shimamura, P. D. Jeffrey, F. M. Hughson
This paper presents the structure of the Vps45–Tlg2 SM–Qa-SNARE complex, showing Vps45 holds Tlg2 in an open conformation, distinct from the closed conformation seen in Munc18-1–syntaxin 1 complexes.
bioRxiv · Jul 1, 2020Cell Biology