Author

P. D. Jeffrey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:structural biology· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

F. M. Hughson· 3 shared S. M. Travis· 2 shared A. E. Stanton· 1 shared A. Hempelmann· 1 shared A. Shajahan· 1 shared B. A. Bensing· 1 shared B. L. Bassler· 1 shared C. E. Stebbins· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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3 shared papersCell Biology

F. M. Hughson

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6 papers

Recent·Most cited

Structure of a Membrane Tethering Complex Incorporating Multiple SNAREs

K. A. DAmico, A. E. Stanton, J. D. Shirkey, S. M. Travis, P. D. Jeffrey, F. M. Hughson

The paper presents a cryo-EM structure of the Dsl1 membrane tethering complex bound to SNAREs, revealing structural similarities to the exocyst complex and suggesting common principles in MTC function.

bioRxiv · Jan 30, 2023Biochemistry

The PqsE active site as a target for small molecule antimicrobial agents against Pseudomonas aeruginosa

I. R. Taylor, P. D. Jeffrey, D. A. Moustafa, J. B. Goldberg, B. L. Bassler

This paper shows that disrupting the PqsE-RhlR interaction reduces P. aeruginosa infection in mice and presents new molecules targeting the PqsE active site.

bioRxiv · Apr 21, 2022Microbiology

The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation

T. Eisemann, F. Allen, K. Lau, G. R. Shimamura, P. D. Jeffrey, F. M. Hughson

This paper presents the structure of the Vps45–Tlg2 SM–Qa-SNARE complex, showing Vps45 holds Tlg2 in an open conformation, distinct from the closed conformation seen in Munc18-1–syntaxin 1 complexes.

bioRxiv · Jul 1, 2020Cell Biology

A Parasite Coat Protein Binds Suramin to Confer Drug Resistance

J. Zeelen, M. van Straaten, J. Verdi, A. Hempelmann, H. Hashemi, K. Perez, P. D. Jeffrey, S. Haelg, N. Wiedemar, P. Maeser, F. N. Papavasiliou, C. E. Stebbins

This study identifies that the trypanosome VSGsur protein binds suramin, conferring drug resistance, and shows this interaction is critical for resistance.

bioRxiv · Jun 4, 2020 · PreprintMicrobiology

Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1

S. M. Travis, K. DAmico, I.-M. Yu, S. Hamid, G. Ramirez-Arellano, P. D. Jeffrey, F. M. Hughson

This paper determines the structural basis of Dsl1 complex binding to ER SNAREs, showing how it anchors the complex and positions SNARE motifs for assembly.

bioRxiv · Apr 7, 2020Cell Biology

Structure and function of accessory Sec proteins involved in the adhesin export pathway of Streptococcus gordonii

Y. Chen, B. A. Bensing, R. Seepersaud, W. Mi, M. Liao, P. D. Jeffrey, A. Shajahan, R. N. Sonon, P. Azadi, P. M. Sullam, T. A. Rapoport

This study investigates the sequential O-glycosylation of an adhesin in Streptococcus gordonii and its interaction with accessory Sec proteins for export.

bioRxiv · Nov 14, 2017Biochemistry