Author

F. M. Hughson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

P. D. Jeffrey· 3 shared S. M. Travis· 2 shared A. E. Stanton· 1 shared F. Allen· 1 shared G. R. Shimamura· 1 shared G. Ramirez-Arellano· 1 shared H. Jin· 1 shared H. Qu· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCell Biology

P. D. Jeffrey

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4 papers

Recent·Most cited

Structure of a Membrane Tethering Complex Incorporating Multiple SNAREs

K. A. DAmico, A. E. Stanton, J. D. Shirkey, S. M. Travis, P. D. Jeffrey, F. M. Hughson

The paper presents a cryo-EM structure of the Dsl1 membrane tethering complex bound to SNAREs, revealing structural similarities to the exocyst complex and suggesting common principles in MTC function.

bioRxiv · Jan 30, 2023Biochemistry

The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation

T. Eisemann, F. Allen, K. Lau, G. R. Shimamura, P. D. Jeffrey, F. M. Hughson

This paper presents the structure of the Vps45–Tlg2 SM–Qa-SNARE complex, showing Vps45 holds Tlg2 in an open conformation, distinct from the closed conformation seen in Munc18-1–syntaxin 1 complexes.

bioRxiv · Jul 1, 2020Cell Biology

Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1

S. M. Travis, K. DAmico, I.-M. Yu, S. Hamid, G. Ramirez-Arellano, P. D. Jeffrey, F. M. Hughson

This paper determines the structural basis of Dsl1 complex binding to ER SNAREs, showing how it anchors the complex and positions SNARE motifs for assembly.

bioRxiv · Apr 7, 2020Cell Biology

Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

J. Jiao, M. He, S. A. Port, R. W. Baker, Y. Xu, H. Qu, Y. Xiong, Y. Wang, H. Jin, T. J. Eisemann, F. M. Hughson, Y. Zhang

This study shows Munc18-1 facilitates SNARE assembly by forming a template complex, and similar mechanisms are used by other SM proteins.

bioRxiv · Sep 10, 2018Biophysics