SLAMF7 engagement super-activates macrophages in acute and chronic inflammation
D. P. Simmons, H. Nguyen, E. Gomez-Rivas, Y. Jeong, A. F. Chen, J. K. Lange, G. S. Dyer, P. Blazar, B. E. Earp, A. M. P. RA/SLE Network, D. A. Rao, E. Y. Kim, M. B. Brenner
This study identifies SLAMF7 as a receptor that super-activates macrophages in inflammatory conditions, leading to increased cytokine expression and inflammation.
bioRxiv · Nov 5, 2020 · PreprintImmunology