Author

D. P. Simmons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

M. B. Brenner· 3 shared S. Raychaudhuri· 2 shared A. F. Chen· 1 shared A. H. Jonsson· 1 shared A. M. P. RA/SLE Network· 1 shared Accelerating Medicines Partnership Program· 1 shared B. E. Earp· 1 shared B. Moody· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

M. B. Brenner

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Author profile →

3 papers

Recent·Most cited

Adipocytes regulate fibroblast function, and their loss contributes to fibroblast dysfunction in inflammatory diseases

H. Faust, T.-Y. Cheng, I. Korsunsky, G. F. M. Watts, S. T. Gal-Oz, W. Trim, K. Kongthong, A. H. Jonsson, D. P. Simmons, F. Zhang, R. Padera, S. Chubinskaya, Accelerating Medicines Partnership Program, K. Wei, S. Raychaudhuri, , M. B. Brenner

The paper shows adipocytes regulate fibroblast function through cortisol signaling, and their loss leads to fibroblast dysfunction in inflammatory diseases.

bioRxiv · May 16, 2023Cell Biology

SLAMF7 engagement super-activates macrophages in acute and chronic inflammation

D. P. Simmons, H. Nguyen, E. Gomez-Rivas, Y. Jeong, A. F. Chen, J. K. Lange, G. S. Dyer, P. Blazar, B. E. Earp, A. M. P. RA/SLE Network, D. A. Rao, E. Y. Kim, M. B. Brenner

This study identifies SLAMF7 as a receptor that super-activates macrophages in inflammatory conditions, leading to increased cytokine expression and inflammation.

bioRxiv · Nov 5, 2020 · PreprintImmunology

CUX1 and IκBζ mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts

K. Slowikowski, H. N. Nguyen, E. H. Noss, D. P. Simmons, F. Mizoguchi, G. F. Watts, M. F. Gurish, M. B. Brenner, S. Raychaudhuri

The paper identifies CUX1 and IκBζ as key mediators of the synergistic inflammatory response to TNF and IL-17A in human synovial fibroblasts, leading to IL-6 production and neutrophil recruitment.

bioRxiv · Mar 11, 2019Immunology