M. B. Brenner

Adipocytes regulate fibroblast function, and their loss contributes to fibroblast dysfunction in inflammatory diseases

The paper shows adipocytes regulate fibroblast function through cortisol signaling, and their loss leads to fibroblast dysfunction in inflammatory diseases.

The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis

The paper identifies chromatin classes in RA synovial tissue and links them to transcriptional cell states and genetic variants.

Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium

This study uses single-cell antigen receptor profiling to identify clonal relationships and functional states of T and B cells in RA synovium.

Clonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis

This study identifies a distinct CD38hi cytotoxic CD8 T cell subset in ICI-induced arthritis, showing clonal expansion and IFN-driven activation.

SLAMF7 engagement super-activates macrophages in acute and chronic inflammation

This study identifies SLAMF7 as a receptor that super-activates macrophages in inflammatory conditions, leading to increased cytokine expression and inflammation.

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

Abuse liability, antinociceptive, and discriminative stimulus properties of IBNtxA

This study evaluates the analgesic, rewarding, and discriminative stimulus properties of IBNtxA, finding it produces potent antinociception with low abuse liability due to κ agonist effects.

CUX1 and IκBζ mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts

The paper identifies CUX1 and IκBζ as key mediators of the synergistic inflammatory response to TNF and IL-17A in human synovial fibroblasts, leading to IL-6 production and neutrophil recruitment.

HBEGF+ macrophages identified in rheumatoid arthritis promote joint tissue invasiveness and are reshaped differentially by medications

A newly identified human macrophage phenotype in RA promotes joint tissue invasiveness and shows variable responses to anti-inflammatory medications.

The immune cell landscape in kidneys of lupus nephritis patients

This study uses single-cell RNA-seq to analyze immune cell subsets in lupus nephritis kidneys, identifying pro-inflammatory and resolving responses and potential therapeutic targets.

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry

The paper identifies key inflammatory cell states in RA synovial tissues using integrated single-cell and mass cytometry data from patient samples.

Single Cell Transcriptomics And Flow Cytometry Reveal Disease-Associated Fibroblast Subsets In Rheumatoid Arthritis

The paper identifies disease-associated fibroblast subsets in rheumatoid arthritis using single-cell transcriptomics and flow cytometry, revealing subset-specific markers and functional differences.