Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
R. P. Ringe, P. Colin, G. Ozorowski, J. Allen, A. Yasmeen, G. Seabright, J. H. Lee, A. Antanasijevic, K. Rantalainen, T. Ketas, J. Moore, A. Ward, M. Crispin, P. J. Klasse
This study investigates how glycan heterogeneity on HIV-1 Env contributes to persistent infectivity despite neutralizing antibody (NAb) treatment, showing that glycan variants affect antibody binding and neutralization efficacy.
bioRxiv · Aug 8, 2023Immunology