R. P. Ringe

Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

This study investigates how glycan heterogeneity on HIV-1 Env contributes to persistent infectivity despite neutralizing antibody (NAb) treatment, showing that glycan variants affect antibody binding and neutralization efficacy.

A broadly protective CHO cell expressed recombinant spike protein subunit based vaccine (IMT-CVAX) against SARS-CoV-2

This paper develops a recombinant spike protein subunit vaccine (IMT-CVAX) against SARS-CoV-2 that elicits broad neutralization against variants and provides protection in animal models.

Enhanced protective efficacy of a novel, thermostable, RBD-S2 fusion immunogen against SARS-CoV-2 and its variants

This study evaluates a novel RBD-S2 fusion immunogen that shows enhanced protection against SARS-CoV-2 and its variants in animal models.

Mutations in S2 subunit of SARS-CoV-2 Omicron spike strongly influence its conformation, fusogenicity and neutralization sensitivity

This study investigates how mutations in the S2 subunit of SARS-CoV-2 Omicron spike affect its structure, fusogenicity, and neutralization sensitivity.

UVC-based air disinfection system for rapid inactivation of SARS-CoV-2 present in the air

This study demonstrates that UVC-based air disinfection systems can rapidly inactivate SARS-CoV-2 in aerosols by damaging its nucleic acids and altering its Spike protein conformation.

Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

This study shows that displaying HIV-1 Env trimers on two-component protein nanoparticles enhances autologous Tier-2 neutralizing antibody titers in rabbits.