J. Allen

PROPEL: a scalable model for postbaccalaureate training to promote diversity in the biomedical workforce

PROPEL is a postbaccalaureate program that trains scholars from underrepresented backgrounds in biomedical research, demonstrating its scalability and impact.

Impact of Glycan Depletion, Glycan Debranching and Increased Glycan Charge on HIV-1 Neutralization Sensitivity and Immunogenicity

This study evaluates glycoengineered HIV-1 trimers to enhance bNAb recognition, finding that B4GalT1+ST6GalT1 modifications increase antibody titers in infected donors but reduce vaccine-induced neutralizing antibodies.

Functionally selective dopamine D1 receptor endocytosis and signaling by catechol and non-catechol agonists

This paper investigates how catechol and non-catechol dopamine D1 receptor agonists induce different signaling and endocytosis patterns, showing that functional selectivity impacts receptor internalization.

Biophysical characterization of high-confidence, small human proteins

The paper characterizes biophysical properties of small human proteins, finding significant differences compared to larger proteins and providing insights for distinguishing functional from non-coding small open reading frames.

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

Pre-existing Immunity to Influenza Aids Ferrets in Developing Stronger and Broader Vaccine-induced Antibody Responses

This study shows that pre-existing immunity in ferrets enhances vaccine-induced antibody responses, reducing the need for booster shots and broadening protection against homologous and heterologous influenza strains.

Genome sequencing and molecular networking analysis of the wild fungus Anthostomella pinea reveal its ability to produce a diverse range of secondary metabolites

This study sequenced the genome of Anthostomella pinea and analyzed its secondary metabolites, revealing 91 biosynthetic gene clusters and the antibiotic xanthoepocin.

3D-intrusions transport active surface microbial assemblages to the dark ocean

The paper shows that ocean subduction creates 3D intrusions transporting surface microbial communities into the dark ocean, altering deep-sea microbial composition and carbon cycling.

Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

This study investigates how glycan heterogeneity on HIV-1 Env contributes to persistent infectivity despite neutralizing antibody (NAb) treatment, showing that glycan variants affect antibody binding and neutralization efficacy.

The genome of Litomosoides sigmodontis illuminates the origins of Y chromosomes in filarial nematodes

This study generates a chromosome-level genome of Litomosoides sigmodontis and shows that filarial Y chromosomes originated from unfused autosomes through X-autosome fusions, not from a neo-Y-linked sex-determining locus.

Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction

The paper identifies targeted therapies that enhance lung cancer vulnerability to macrophage attack when combined with anti-CD47 antibodies, showing synergy across multiple genetic mutations.

MMD scaffolds ACSL4 and MBOAT7 to promote polyunsaturated phospholipid synthesis and susceptibility to ferroptosis

This paper identifies MMD as a scaffold protein that promotes ferroptosis by facilitating the synthesis of arachidonoyl-phospholipids through interactions with ACSL4 and MBOAT7.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

The paper uses proximity labeling to identify protein complexes associated with Rab4, Rab11a, and Rab25 in cancer cells, revealing their roles in endocytic recycling and cell migration.

Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens

This paper engineers HIV-1 envelope trimers with enhanced V2 and fusion peptide neutralization sensitivity for vaccine development.

Modulating the unfolded protein response: Impacts of radiation on the response of prostate cancer cells to ONC201

This study investigates how radiation and ONC201 modulate the unfolded protein response (UPR) in prostate cancer cells, enhancing cell death and radiosensitivity.

Two sides of a coin: a Zika virus mutation selected in pregnant rhesus macaques promotes fetal infection in mice but at a cost of reduced fitness in nonpregnant macaques and diminished transmissibility by vectors

This paper identifies a ZIKV mutation, M1404I, that enhances fetal infection in mice but reduces viral fitness and transmissibility in nonpregnant macaques and mosquitoes.

Intrinsic and extrinsic factors collaborate to activate pharyngeal satellite cells without muscle injury

This study identifies intrinsic and extrinsic factors that drive increased basal activity of pharyngeal satellite cells compared to limb muscle satellite cells.

Integrated single cell and bulk multi-omics reveals heterogeneity and early changes in pathways associated with cetuximab resistance in HNSCC sensitive cell lines

The paper uses single cell and bulk multi-omics to study early resistance mechanisms in HNSCC cells treated with cetuximab, identifying TFAP2A and EMT as independent pathways.

FDA-ARGOS: A Public Quality-Controlled Genome Database Resource for Infectious Disease Sequencing Diagnostics and Regulatory Science Research

The paper introduces FDA-ARGOS, a quality-controlled genome database for infectious disease sequencing, and demonstrates its use in diagnostics and validation.

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

The paper describes the structure of a chimpanzee SIV Env trimer and shows it induces HIV V2-specific neutralizing antibodies in mice.

Lung Cancer Explorer (LCE): an open web portal to explore gene expression and clinical associations in lung cancer

The paper constructs a lung cancer database with gene expression and clinical data from 6,700 patients and develops an open web portal for data exploration and analysis.

First genome-wide analysis of an endangered lichen reveals isolation by distance and strong population structure

The paper analyzes the population genomics of Cetradonia linearis to assess the role of geographic distance versus environmental factors in shaping genetic structure and reveals low recombination rates and isolation by distance.

Quantitative mass imaging of single molecules in solution

This paper introduces a method to mass-image single biomolecules in solution with high precision and resolution, enabling the study of molecular interactions and assemblies.