Structural Basis for Allosteric Control of the SERCA-Phospholamban Membrane Complex by Ca2+ and cAMP-dependent Phosphorylation
D. K. Weber, M. S. Hernandez, V. U. Reddy, S. Wang, E. K. Larsen, G. Tata, M. Gustavsson, R. L. Cornea, D. D. Thomas, A. De Simone, G. Veglia
This study reveals how phosphorylation and Ca2+ modulate the SERCA-PLN complex through structural changes that enhance Ca2+ transport.
bioRxiv · Aug 28, 2020 · PreprintBiophysics