Author

M. Gustavsson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

C. T. Schafer· 2 shared T. M. Handel· 2 shared A. A. Kossiakoff· 1 shared A. De Simone· 1 shared B. S. Stephens· 1 shared D. D. Thomas· 1 shared D. K. Weber· 1 shared D. P. Millar· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiophysics

C. T. Schafer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes

C. T. Schafer, R. F. Pauszek, M. Gustavsson, T. M. Handel, D. P. Millar

This study uses single-molecule FRET to compare conformational dynamics of CXCR4 and ACKR3, revealing distinct activation mechanisms and conformational landscapes.

bioRxiv · Oct 31, 2023Biophysics

ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding

Q. Chen, C. T. Schafer, S. Mukherjee, M. Gustavsson, P. Agrawal, X.-Q. Yao, A. A. Kossiakoff, T. Handel, J. J. G. Tesmer

This paper reports cryo-EM structures of ACKR3-arrestin2/3 complexes phosphorylated by GRK2 or GRK5, revealing how phosphorylation barcodes influence arrestin binding modes and receptor configuration.

bioRxiv · Jul 18, 2023 · PreprintBiochemistry

Transformers enable accurate prediction of acute and chronic chemical toxicity in aquatic organisms

M. Gustavsson, S. Kall, P. Svedberg, J. S. Inda-Diaz, S. Molander, J. Coria, T. Backhaus, E. Kristiansson

This paper develops a transformer-based model to predict chemical toxicity in aquatic organisms, achieving high accuracy and broader applicability than traditional QSAR methods.

bioRxiv · Apr 17, 2023Pharmacology & Toxicology

Structural Basis for Allosteric Control of the SERCA-Phospholamban Membrane Complex by Ca2+ and cAMP-dependent Phosphorylation

D. K. Weber, M. S. Hernandez, V. U. Reddy, S. Wang, E. K. Larsen, G. Tata, M. Gustavsson, R. L. Cornea, D. D. Thomas, A. De Simone, G. Veglia

This study reveals how phosphorylation and Ca2+ modulate the SERCA-PLN complex through structural changes that enhance Ca2+ transport.

bioRxiv · Aug 28, 2020 · PreprintBiophysics

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

T. Ngo, B. S. Stephens, M. Gustavsson, L. G. Holden, R. Abagyan, T. M. Handel, I. Kufareva

This paper determines the structure of the CXCR4-CXCL12 complex using crosslinking, revealing the geometry and selectivity determinants of CXC receptor-chemokine interactions.

bioRxiv · Jan 10, 2020Biochemistry