S. Minucci

Automated workflow for the cell cycle analysis of non-adherent and adherent cells using a machine learning approach

This paper introduces an automated method for analyzing the cell cycle in both adherent and non-adherent cells using machine learning, validated in AML cell lines and drug response testing.

LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness.

This study shows that inhibiting LSD1 enhances CD8+ T cell function in adoptive T cell therapy, leading to improved antitumor immunity and synergistic effects with anti-PDL1 therapy.

Metformin antiproliferative activity is exclusively mediated by the membrane functional expression of the Chloride Intracellular Channel 1 in glioblastoma stem cells

This study identifies tmCLIC1 as the specific metformin receptor in glioblastoma stem cells, showing that metformin's antiproliferative effect depends on its binding to tmCLIC1 and subsequent inhibition of mitochondrial respiration.

Goat PRP14 (gPRP14) has xeno-antigenic properties and works as a vaccine in preclinical models of cancer.

This study characterizes gPRP14 as a tumor-specific xeno-antigen that induces anti-tumor immunity in preclinical cancer models.

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia

This study uses longitudinal single-cell transcriptomics to analyze AML recurrence patterns, finding varying transcriptional changes between diagnosis and relapse that challenge the clonal evolution model.

Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity

The paper shows inhibiting LSD1 reduces coronavirus-induced inflammation while preserving innate antiviral activity in macrophages.

Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1, a novel oncogene in AML

This study shows that LSD1 inhibitors induce AML cell differentiation by reducing GSE1, a novel oncogene, through transcriptional activation of immune response genes.

Single cell derived organoids capture the self-renewing subpopulations of metastatic ovarian cancer

This study develops a method to grow single-cell derived ovarian cancer organoids from patient ascites, which retain key subpopulations and features of the original metastasis not seen in 2D cultures.