Rosalind Helen Gunby

Endocytic control of cell-autonomous and non-cell-autonomous functions of p53

This study shows that NUMB's Ex3 exon directs it to the plasma membrane, forming a complex with SNX9 that recruits and transports p53 via exosomes, enabling p53-dependent transcriptional activity in recipient cells.

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB Levels

The paper identifies the CRL7FBXW8 complex as an E3 ligase responsible for NUMB hyper-degradation in breast cancer, showing its inhibition rescues transformation phenotypes.

Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitry

This study identifies Numb loss as a driver of aggressive bladder cancer through hyperactivation of the RhoA/ROCK/YAP signaling pathway, proposing a 27-gene signature for clinical stratification.