Author

Maria Grazia Filippone

University of Milan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Daniela TosoniiD· 3 shared Salvatore PeceiD· 3 shared Francesco Antonio TucciiD· 2 shared Giovanni BertalotiD· 2 shared Pier Paolo Di FioreiD· 2 shared Rosalind Helen GunbyiD· 2 shared Stefano FreddiiD· 2 shared Alessandro SarcinellaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Daniela TosoniORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

p140Cap enhances breast cancer chemosensitivity by limiting an ABCC1-enriched stem-like compartment via β-Catenin inhibition

Andrea Scavuzzo, Matteo Poncina, Alessia Lamolinara, Alessandro Sarcinella, Mahdis Jahanbin, Maria Grazia Filippone, Laura Bottoni, Francesco Antonio Tucci, Yaron Vinik, Sima Lev, Manuela Iezzi, Ugo Ala, Daniela Taverna, Francesca Orso, Barbara Belletti, , Vincenzo Salemme

This study shows p140Cap improves chemotherapy response in breast cancer by reducing stem-like cells and enhancing drug retention through β-Catenin inhibition.

bioRxiv · Aug 18, 2026 · PreprintCancer Biology

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB Levels

Simone Sabbioni, Maria Grazia Filippone, Letizia Amadori, Stefano Confalonieri, Roberta Bonfanti, Stefano Capoano, Ivan Nicola Colaluca, Stefano Freddi, Giovanni Bertalot, Giovanni Fagà, Elisa Zagarrí, Mario Varasi, Rosalind Helen Gunby, Ciro Mercurio, Salvatore Pece, , Daniela Tosoni

The paper identifies the CRL7FBXW8 complex as an E3 ligase responsible for NUMB hyper-degradation in breast cancer, showing its inhibition rescues transformation phenotypes.

Advanced Science · May 24, 2025Peer-reviewedCancer Biology

Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitry

Francesco Antonio Tucci, Rosa Pennisi, Damiano Cosimo Rigiracciolo, Maria Grazia Filippone, R. Bonfanti, F. Romeo, Stefano Freddi, Elisa Guerrera, Chiara Soriani, Simona Rodighiero, Rosalind Helen Gunby, Giovanna Jodice, Francesca Sanguedolce, Giuseppe Renne, Nicola Fusco, , Salvatore Pece

This study identifies Numb loss as a driver of aggressive bladder cancer through hyperactivation of the RhoA/ROCK/YAP signaling pathway, proposing a 27-gene signature for clinical stratification.

Nature Communications · Dec 3, 2024Peer-reviewedCancer Biology