G. W. G. Luxton

This study investigates how torsinA, a luminal AAA+ ATPase, mediates nuclear-cytoplasmic communication by adopting distinct functional assembly states during LINC complex and NPC biogenesis.

This paper develops a cell-free system to study LINC complex assembly by reconstituting membrane proteins in lipid bilayers and shows its utility in investigating chemical and molecular factors affecting protein interactions.

This study identifies imbalanced nucleocytoskeletal connections as a cause of polarity defects in progeria and aging, showing that rebalancing these connections can restore normal cell function.