A. P. Liu

Cellular mechanotransduction of human osteoblasts in microgravity

This study investigates how microgravity affects human fetal osteoblasts by measuring cell mechanics and signaling changes in space compared to ground controls.

Matrix confinement modulates 3D spheroid sorting and burst-like collective migration

This study shows that matrix confinement affects 3D spheroid sorting and collective migration, with sorting dependent on cell-cell adhesion and matrix resistance.

Mechanosensitive channel-based optical membrane tension biosensor

The paper develops an optical biosensor to measure membrane tension by repurposing an E. coli mechanosensitive channel with circularly permuted GFP.

Differential regulation of GUV mechanics via actin network architectures

This study shows that actin network architecture and lumenal viscosity regulate GUV deformability, with crosslinkers and dendritic cortex reducing deformability compared to actin filaments alone.

Compressive stress drives adhesion-dependent unjamming transitions in breast cancer cell migration

This study identifies compressive stress as a driver of unjamming transitions in breast cancer cell migration by showing that cell-cell adhesion, not epithelial-mesenchymal transition, mediates these changes.

Encapsulated actomyosin patterns drive cell-like membrane shape changes

The paper shows that actomyosin networks in lipid vesicles form ring and aster patterns, driving membrane constriction and deformation through myosin-driven remodeling.

Biomechanics and Myofibrillar Alignment Enhance Contractile Development and Reproducibility in Stem Cell Derived Cardiac Muscle

This study develops a 2D platform to enhance contractile development and reproducibility in stem cell-derived cardiac muscle by controlling biomechanics and myofibrillar alignment.

In vitro synthesis and reconstitution using mammalian cell-free lysates enables the systematic study of the regulation of LINC complex assembly

This paper develops a cell-free system to study LINC complex assembly by reconstituting membrane proteins in lipid bilayers and shows its utility in investigating chemical and molecular factors affecting protein interactions.

Myofibrillar Structural Variability Underlies Contractile Function in Stem Cell-Derived Cardiomyocytes

This study shows myofibrillar structure variability in iPSC-derived cardiomyocytes affects contractile function and should be considered in disease modeling and drug testing.

Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture

The paper shows that actin crosslinker competition and sorting in confined environments lead to distinct actin network architectures in GUVs.

β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling

The paper identifies a third mechanism of intracellular GPCR signaling independent of ligands and endocytosis, mediated by β-arrestin-1.

Complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension

The paper shows epsin's structured and unstructured domains work together to support clathrin-mediated endocytosis under high membrane tension.

Acute decrease in plasma membrane tension induces macropinocytosis via PLD2 activation

The paper shows that acute plasma membrane tension decrease triggers macropinocytosis through PLD2 activation and phosphatidic acid production in myoblasts.

Compressive Stress Enhances Invasive Phenotype of Cancer Cells via Piezo1 Activation

This study shows compressive stress enhances breast cancer cell invasion via Piezo1 activation, leading to increased matrix degradation and invadopodia formation.

Loss Of PTEN Promotes Formation Of Signaling-Capable Clathrin-Coated Pits

This study shows PTEN regulates clathrin-coated pit dynamics by modulating PI(3,4,5)P3 levels, promoting short-lived signaling-capable CCPs in cancer cells.