ImmunologybioRxiv
Loss of mitochondrial protease CLPP activates type I interferon responses through the mtDNA-cGAS-STING signaling axis
S. Torres-Odio, Y. Lei, S. Gispert…·A. P. West
This study shows that CLPP deficiency causes mtDNA stress, which activates the cGAS-STING pathway and leads to type I interferon responses and antiviral gene expression.
DOI 10.4049/jimmunol.2001016