J. Key

The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5

This study identifies ATM's role in regulating vesicular protein secretion through CHGA and microtubule dynamics via CRMP5 in neurons, linking A-T neural atrophy to growth cone collapse.

Loss of mitochondrial protease CLPP activates type I interferon responses through the mtDNA-cGAS-STING signaling axis

This study shows that CLPP deficiency causes mtDNA stress, which activates the cGAS-STING pathway and leads to type I interferon responses and antiviral gene expression.