Author

G.-A. Lu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Y. Zhao· 3 shared C.-I. Wu· 2 shared J. Xu· 2 shared P. Lin· 2 shared T. Tang· 2 shared Z. Liufu· 2 shared A. Lan· 1 shared H. Wen· 1 shared

Activity by Year

2018-2022 · peak 1/yr

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10 top collaborators · 34 mutual co-author links

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3 shared papersEvolutionary Biology

Y. Zhao

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3 papers

Recent·Most cited

Gene expression as phenotype - Many small-step changes leading to little long-term phenotypic evolution

P. Lin, G.-A. Lu, Z.-Q. Liufu, Y. Zhao, Y.-S. Ruan, C.-I. Wu, H.-J. Wen

The paper tests the Fishers Geometric Model postulate by analyzing gene expression data, showing that small-step evolution via miRNA regulation is common but does not lead to long-term phenotypic changes.

bioRxiv · Jun 24, 2022 · PreprintEvolutionary Biology

Run or die in the evolution of new microRNAs - Testing the Red Queen hypothesis on de novo new genes

Y. Zhao, G.-A. Lu, H. Yang, P. Lin, Z. Liufu, T. Tang, J. Xu

The paper tests the Red Queen hypothesis by analyzing two Drosophila de novo miRNAs, finding their fitness contributions vary between species, supporting their different evolutionary fates.

bioRxiv · Jun 15, 2020Evolutionary Biology

Mechanisms of gene death in the Red Queen race revealed by the analysis of de novo microRNAs

G.-A. Lu, Y. Zhao, A. Lan, Z. Liufu, H. Wen, T. Tang, J. Xu, C.-I. Wu

The paper investigates how de novo microRNAs in Drosophila affect male fitness and reveals that adaptive de novo genes may die due to canceling fitness effects, suggesting quasi-neutrality and ongoing period-specific adaptations.

bioRxiv · Jun 17, 2018Evolutionary Biology