Author

H.-J. Wen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

H. C. Crawford· 3 shared N. G. Steele· 3 shared C.-I. Wu· 2 shared D. Long· 2 shared E. T. Davis· 2 shared M. T. Hoffman· 2 shared P. Lin· 2 shared S. Benitz· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

H. C. Crawford

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer

D. J. Salas-Escabillas, M. T. Hoffman, J. S. Moore, S. M. Brender, H.-J. Wen, S. Benitz, E. T. Davis, D. Long, A. M. Wombwell, N. G. Steele, R. C. Sears, I. Matsumoto, K. E. DelGiorno, H. C. Crawford

The paper shows that metaplastic tuft cells in pancreatic cancer transdifferentiate into neural-like progenitor cells, driven by Myc activity, and this transition is linked to poor patient survival.

bioRxiv · Feb 12, 2024Cancer Biology

ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma

S. Benitz, A. Steep, M. Nasser, J. Preall, U. M. Mahajan, H. McQuithey, I. Loveless, E. T. Davis, H.-J. Wen, D. W. Long, T. Metzler, S. Zwernik, M. Louw, D. Rempinski, D. Salas-Escabillas, , H. C. Crawford

This study identifies ROR2 as a regulator of cellular plasticity in pancreatic neoplasia, showing it promotes an aggressive PDAC phenotype and resistance to KRAS inhibitors.

bioRxiv · Dec 13, 2023Cancer Biology

Gene expression as phenotype - Many small-step changes leading to little long-term phenotypic evolution

P. Lin, G.-A. Lu, Z.-Q. Liufu, Y. Zhao, Y.-S. Ruan, C.-I. Wu, H.-J. Wen

The paper tests the Fishers Geometric Model postulate by analyzing gene expression data, showing that small-step evolution via miRNA regulation is common but does not lead to long-term phenotypic changes.

bioRxiv · Jun 24, 2022 · PreprintEvolutionary Biology

Homo-harringtonine (HHT) - A highly effective drug against coronaviruses and the potential for large-scale clinical applications

H.-J. Wen, P. Lin, G.-X. Zhong, Z.-C. Xu, L. Shuai, Z.-Y. Wen, C. Wang, X. Cao, W.-B. He, J. Feng, Q.-C. Cai, H.-J. Ma, S.-J. Wu, G.-D. Wang, X.-M. Lyu, , C.-I. Wu

The paper identifies Homo-harringtonine (HHT) as a potent antiviral drug against coronaviruses, effective in mouse models and safe in dogs, with potential for large-scale clinical use.

bioRxiv · Apr 16, 2021 · PreprintMicrobiology

The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2

S. A. Kerk, L. Lin, A. L. Myers, Y. Zhang, J. A. Jimenez, P. Sajjakulnukit, B. S. Nelson, B. Chen, A. Robinson, G. Thurston, S. B. Kemp, N. G. Steele, M. T. Hoffman, H.-J. Wen, D. Long, , C. A. Lyssiotis

This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.

bioRxiv · Aug 7, 2020Cancer Biology