Synthetic glabridin derivatives mitigate steatohepatitis in a diet-induced biopsy-confirmed non-alcoholic steatosis hepatitis mouse model through paraoxonase-2
G.-C. Shin, H. M. Lee, N. Y. Kim, S.-K. Yoo, Y. S. Park, H. S. Park, D. Ryu, K. P. Kim, K.-H. Kim
This study shows synthetic glabridin derivatives reduce NASH symptoms in mice by activating autophagy and antioxidant defenses through targeting paraoxonase-2.
bioRxiv · Oct 1, 2021 · PreprintPharmacology & Toxicology