Adopting Duplex Sequencing Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed Rats
Stephanie L. Smith‐Roe, Cheryl A. Hobbs, Victoria Hull, J. Todd Auman, Leslie Recio, Michael A. Streicker, Miriam V. Rivas, Gabriel A. Pratt, Fang Yin Lo, Jacob E. Higgins, Elizabeth K. Schmidt, Lindsey N. Williams, Daniela Nachmanson, Charles C. Valentine, Jesse J. Salk, Kristine L. Witt
This paper evaluates a DuplexSeq-based mutagenesis assay in ENU-exposed rats, showing early detection of mutations and reproducible results across tissues and labs.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis · Aug 2, 2023Peer-reviewedGenomics