Author

Jacob E. Higgins

ORCID 0000-0002-4984-5456Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:whole-genome sequencing· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Jesse J. SalkiD· 3 shared Charles C. ValentineiD· 2 shared Daniela NachmansoniD· 2 shared Elizabeth K. SchmidtiD· 2 shared Fang Yin LoiD· 2 shared Thomas Horace SmithiD· 2 shared Alison F. FederiD· 1 shared Ann DohertyiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCancer Biology

Jesse J. SalkORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 20, 2026

✦ In-depth digest

Ultra-deep duplex sequencing reveals unique features of somatic evolution in the normal tissues of a family with Li-Fraumeni syndrome

Hunter Colegrove, Marianne E. Dubard-Gault, Henry Marshall…·Rosa Ana Risques

Duplex sequencing of a Li-Fraumeni family links germline TP53 p.R181H to higher neutral-region mutagenesis and weaker blood TP53 selection, plus recurrent p.R248Q/W hits across proband tissues.

DOI 10.64898/2026.01.12.699071

humanwhole-genome sequencing

𝕏 PostBluesky

Pharmacology & ToxicologyArchives of ToxicologyPeer-reviewedJul 17, 2025

Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis

Anne L. Ashford, Daniela Nachmanson, John W. Wills…·Anthony M. Lynch

This study aligns Duplex Sequencing with transgenic rodent mutation assay data to assess in vivo NDMA-induced mutagenesis, finding dose-dependent mutation frequency increases and concordant benchmark dose estimates.

13 citationstop 3%

mouseDNA methylation

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GenomicsMutation Research/Genetic Toxicology and Environmental MutagenesisPeer-reviewedAug 2, 2023

Adopting Duplex Sequencing Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed Rats

Stephanie L. Smith‐Roe, Cheryl A. Hobbs, Victoria Hull…·Kristine L. Witt

This paper evaluates a DuplexSeq-based mutagenesis assay in ENU-exposed rats, showing early detection of mutations and reproducible results across tissues and labs.

23 citations

ratwhole-genome sequencing

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