Extrachromosomal circular DNA promotes inflammation and hepatocellular carcinoma development
Lap Kwan Chan, Juanjuan Shan, Elias Rodríguez-Fos, Marc Eammonn Healy, Peter Leary, Rossella Parrotta, Nina Desboeufs, Gabriel Semere, Nadine Wittstruck, Anton George Henssen, Achim Weber
The paper shows that extrachromosomal circular DNA (eccDNA) from micronuclei promotes inflammation and hepatocellular carcinoma (HCC) development through the cGAS-STING pathway.
Science Advances · Oct 17, 2025Peer-reviewedCancer Biology