Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state
Elizabeth A. Thayer, Gabriela Shipman, Joel Rivera-Cardona, Tarun Mahajan, Qi Wen Teo, Jassir Páez, Joseph Lederer, Jie Chen, Nicholas C. Wu, Sergei Maslov, Christopher B. Brooke
The paper shows that single-cell heterogeneity in IFN induction potential is heritable and driven by baseline variation in JNK and AP-1 signaling states.
Cell Systems · Jul 16, 2026Peer-reviewedSystems Biology