PGM3 inhibition rewires RUVBL2-dependent DNA repair and induces a BRCAness-like state in pancreatic cancer cells
Barbara Zerbato, Gabriele Taverna, Marina La Chimia, Marilena Pontoriero, Silvia Lombardi, Lorenzo Taglietti, Ke Deng, Giulia Chiara Maria Perrone, Sini Hakkola, Alma Vuori, Teemu Syriala, Emmanuel de Billy, Silvia M.L. Barabino, Cinzia Bragato, Ciro Leonardo Pierri, , Ferdinando Chiaradonna
This study shows that inhibiting PGM3 in pancreatic cancer cells disrupts DNA repair pathways, induces a BRCAness-like state, and increases sensitivity to PARP inhibitors and radiation.
bioRxiv · Sep 1, 2026 · PreprintCancer Biology