Sini Hakkola

PGM3 inhibition rewires RUVBL2-dependent DNA repair and induces a BRCAness-like state in pancreatic cancer cells

This study shows that inhibiting PGM3 in pancreatic cancer cells disrupts DNA repair pathways, induces a BRCAness-like state, and increases sensitivity to PARP inhibitors and radiation.

AR suppression rewires a SOX4 regulatory program to promote enzalutamide resistance in prostate cancer

The paper identifies a SOX4-driven regulatory program that promotes enzalutamide resistance in prostate cancer by rewiring gene regulation following AR suppression.

Deep Invaginations of Nuclear Envelope Coordinate Spatial Organization of Chromatin in Epithelium

The paper identifies deep nuclear envelope invaginations (DINEs) in epithelial cells, showing they organize chromatin and gene activity in response to mechanical cues like crowding and tissue maturation.

Deep phenotyping of the prostate tumor microenvironment reveals molecular stratifiers of relapse and links inflammatory chemokine expression to aberrant metabolism

The paper identifies molecular signatures in prostate cancer that link inflammatory chemokine expression to metabolic changes and relapse risk.