Author

Lorenzo Taglietti

University of Milano-BicoccaORCID 0009-0002-5306-6583Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Alfonso UrbanucciiD· 1 shared Alma Vuori· 1 shared Barbara La FerlaiD· 1 shared Barbara ZerbatoiD· 1 shared Cinzia BragatoiD· 1 shared Ciro Leonardo PierriiD· 1 shared Domenica ScumaciiD· 1 shared Emmanuel de BillyiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alfonso UrbanucciORCID

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1 paper

Recent·Most cited

PGM3 inhibition rewires RUVBL2-dependent DNA repair and induces a BRCAness-like state in pancreatic cancer cells

Barbara Zerbato, Gabriele Taverna, Marina La Chimia, Marilena Pontoriero, Silvia Lombardi, Lorenzo Taglietti, Ke Deng, Giulia Chiara Maria Perrone, Sini Hakkola, Alma Vuori, Teemu Syriala, Emmanuel de Billy, Silvia M.L. Barabino, Cinzia Bragato, Ciro Leonardo Pierri, , Ferdinando Chiaradonna

This study shows that inhibiting PGM3 in pancreatic cancer cells disrupts DNA repair pathways, induces a BRCAness-like state, and increases sensitivity to PARP inhibitors and radiation.

bioRxiv · Sep 1, 2026 · PreprintCancer Biology