E2f coordinates the proliferation and transdifferentiation of a Sox9+bile duct cell to initiate hepatocellular carcinoma
Gabriella Crosier, Eunsun Kim, Katharina E. Hayer, Emma Elizabeth Furth, Patrick Viatour
This study shows that E2f activation in Sox9+ bile duct cells drives proliferation and transdifferentiation into hepatocytes, initiating hepatocellular carcinoma.
bioRxiv · Sep 18, 2025 · PreprintCancer Biology