Cancer BiologybioRxivPreprint
E2f coordinates the proliferation and transdifferentiation of a Sox9+bile duct cell to initiate hepatocellular carcinoma
Gabriella Crosier, Eunsun Kim, Katharina E. Hayer…·Patrick Viatour
This study shows that E2f activation in Sox9+ bile duct cells drives proliferation and transdifferentiation into hepatocytes, initiating hepatocellular carcinoma.
DOI 10.1101/2025.09.18.677170