Katharina E. Hayer

HSV-1 hijacks the DNA repair protein RAD51 at gene promoters to drive viral transcription

This study shows HSV-1 uses RAD51 to enhance viral gene expression by binding to promoter regions and interacting with ADNP.

The ancestral haplotype of P2RX5 yields a B-cell surface marker and a multi-lineage immunotherapy target

The paper identifies P2RX5 as a new B-cell surface marker and multi-lineage immunotherapy target, showing its expression in B-cell malignancies and T-cell leukemia, and demonstrating the efficacy of P2RX5-directed therapies.

Alternative splicing in pediatric central nervous system tumors highlights oncofetal candidate CLK1 exon 4

The paper analyzes splicing in 729 pediatric brain tumors, identifies splicing-defined subgroups, and highlights CLK1 exon 4 as an oncofetal event linked to tumor prognosis.

E2f coordinates the proliferation and transdifferentiation of a Sox9+bile duct cell to initiate hepatocellular carcinoma

This study shows that E2f activation in Sox9+ bile duct cells drives proliferation and transdifferentiation into hepatocytes, initiating hepatocellular carcinoma.

NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas

The paper identifies a NRCAM proteoform with skipped microexons as a targetable surface antigen in pHGG and demonstrates its utility in immunotherapy.

E2f coordinates the cell cycle and cell fate of hematopoietic progenitors to drive stress myelopoiesis

This study identifies E2f as a regulator that coordinates cell cycle activity and cell fate decisions in hematopoietic progenitors to drive stress myelopoiesis.

Cell type-specific enhancers regulate IL-22 expression in innate and adaptive lymphoid cells

The paper identifies two enhancers regulating IL-22 expression in type 3 lymphoid cells, showing distinct roles in different subsets and functions in disease models.

Promoter- and Enhancer-Dependent Cohesin Loading Initiates Chromosome Looping to Fold Tcrb Loci for Long-Range Recombination

The paper shows that cohesin loading from Vβ promoters or enhancers initiates loop extrusion across the Tcrb locus, enabling long-range recombination.

The SMC5/6 complex is required for maintenance of genome integrity upon APOBEC3A-mediated replication stress

This study identifies the SMC5/6 complex as essential for genome stability in cells with active APOBEC3A, showing that its loss leads to increased DNA damage and replication stress.

Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing

The paper uses direct RNA long-read sequencing to show m6A modifications on adenovirus RNA are necessary for efficient splicing.

The role of SRSF3 splicing factor in generating circular RNAs

The paper investigates the role of SRSF3 in circRNA biogenesis and identifies its impact on circRNA production and potential involvement in hematologic malignancies.