Loss of Lamp2a-dependent chaperone-mediated autophagy drives dry AMD-like retinal pathology in mice and is rescued by BK channel activation
Hilal Ahmad Mir, Gaddam Mahesh, Arunan Palanimuthu, Christopher L. Cioffi, Konstantin E. Petrukhin
This study shows that loss of CMA in mice leads to AMD-like retinal pathology, which is reversed by activating BK channels with GLA-1-1.
bioRxiv · Mar 23, 2026 · PreprintPharmacology & Toxicology