Author

Christopher L. Cioffi

Rensselaer Polytechnic InstituteORCID 0000-0003-0642-7905Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Organism:virus· 1

Frequent Co-Authors

Ada QuinniD· 1 shared Anna E. TischeriD· 1 shared Arunan Palanimuthu· 1 shared Azadeh ShahsavariD· 1 shared Billy J. Williams‐NoonaniD· 1 shared Davide SilvestriiD· 1 shared Gaddam Mahesh· 1 shared Gaetano Thomas MontelioneiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperNeuroscience

Ada QuinnORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintMar 23, 2026

Loss of Lamp2a-dependent chaperone-mediated autophagy drives dry AMD-like retinal pathology in mice and is rescued by BK channel activation

Hilal Ahmad Mir, Gaddam Mahesh, Arunan Palanimuthu…·Konstantin E. Petrukhin

This study shows that loss of CMA in mice leads to AMD-like retinal pathology, which is reversed by activating BK channels with GLA-1-1.

DOI 10.64898/2026.03.19.712761

mouseexperimental assay

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NeurosciencebioRxivPreprintApr 21, 2025

A reversible allosteric inhibitor of GlyT2 alleviates neuropathic pain without on-target side effects

Ryan Cantwell Chater, Julian Peiser-Oliver, Tanmay K. Pati…·Azadeh Shahsavar

This paper develops a reversible GlyT2 inhibitor that alleviates neuropathic pain without on-target side effects or addiction liability.

1 citation

mouseexperimental assay

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BiochemistryScientific ReportsPeer-reviewedDec 31, 2024

An isothermal calorimetry assay for determining steady state kinetic and enzyme inhibition parameters for SARS-CoV-2 3CL-protease

Luca Mazzei, Sofia Ranieri, Davide Silvestri…·Stefano Ciurli

This paper develops an ITC assay to measure kinetic and inhibition parameters of SARS-CoV-2 3CL-protease, revealing two inhibition modes and deriving kinetic constants with high precision.

7 citations

virusexperimental assay

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