Konstantin E. Petrukhin

A non-retinoid triazolopyrimidine RBP4 antagonist for the treatment of Stargardt disease

This paper describes a non-retinoid RBP4 antagonist, AKR-XI-85, that reduces lipofuscin accumulation in a mouse model of Stargardt disease.

Loss of Lamp2a-dependent chaperone-mediated autophagy drives dry AMD-like retinal pathology in mice and is rescued by BK channel activation

This study shows that loss of CMA in mice leads to AMD-like retinal pathology, which is reversed by activating BK channels with GLA-1-1.