Continuous target-specific mutagenesis and rapid gene evolution by diversity-generating retroelements in Escherichia coli
Yang Liu, Yangqi Gu, Ganesh Agam, Fabian B. H. Rehm, Martin Spinck, Jason W. Chin, Philipp Holliger
This paper demonstrates a system using DGRs in E. coli to perform continuous, targeted mutagenesis of genes, enabling rapid evolution of specific sequences.
bioRxiv · Jul 23, 2026 · PreprintSynthetic Biology