Martin Spinck

This paper demonstrates a system using DGRs in E. coli to perform continuous, targeted mutagenesis of genes, enabling rapid evolution of specific sequences.

This paper introduces a method for continuous site-directed mutagenesis and selection in E. coli to generate diverse genetic libraries efficiently.

This paper describes the creation of a synthetic Escherichia coli strain with a 57-codon genetic code by recoding 105 codons in a 4 Mb synthetic genome.