Jason W. Chin

This paper demonstrates a system using DGRs in E. coli to perform continuous, targeted mutagenesis of genes, enabling rapid evolution of specific sequences.

This paper introduces a method for continuous site-directed mutagenesis and selection in E. coli to generate diverse genetic libraries efficiently.

This paper expands the genetic code by incorporating non-canonical monomers into proteins using evolved tRNAs and orthogonal synthetases, enabling broader sequence context compatibility.

This paper introduces an improved orthogonal replication system in E. coli that enables rapid gene evolution with high mutation rates and demonstrates its application in evolving ethanol assimilation pathways.

This paper describes the creation of a synthetic Escherichia coli strain with a 57-codon genetic code by recoding 105 codons in a 4 Mb synthetic genome.

The paper shows that astrocytic GABA transporters regulate extracellular GABA levels in the SCN, which in turn controls circadian time-keeping through neuronal inhibition.

This study identifies RBBP6 as a critical factor required for human CPSF-mediated pre-mRNA 3'-end processing, showing its RNA-dependent recruitment and interaction with CPSF subunits.

The paper presents the cryo-EM structure of the bacterial SMC complex MukBEF in complex with MatP and DNA, revealing how it entraps DNA loops at unloading sites.

This study uses genetic code expansion and optical targeting in C. elegans to selectively activate gene expression in specific neurons and analyze their role in behavior.

The paper develops a FRET-based sensor to study EGFR conformational changes and identifies an autocatalytic mechanism in EGFR activation.