Fabian B. H. Rehm

This paper demonstrates a system using DGRs in E. coli to perform continuous, targeted mutagenesis of genes, enabling rapid evolution of specific sequences.

This paper introduces a method for continuous site-directed mutagenesis and selection in E. coli to generate diverse genetic libraries efficiently.

This paper introduces an improved orthogonal replication system in E. coli that enables rapid gene evolution with high mutation rates and demonstrates its application in evolving ethanol assimilation pathways.

This paper describes the creation of a synthetic Escherichia coli strain with a 57-codon genetic code by recoding 105 codons in a 4 Mb synthetic genome.