HIV protease inhibitor Saquinavir inhibits toll-like receptor 4 activation by targeting receptor dimerization
Cheng Peng, Gang Deng, Yong Wang, Alzahrani Walid Abdulwahab, Hongwu Luo, Feizhou Huang, Hongbo Xu
This study shows that Saquinavir inhibits both MyD88- and TRIF-dependent TLR4 signaling pathways by blocking receptor dimerization, suggesting it targets the TLR4 receptor complex.
bioRxiv · May 23, 2018 · PreprintImmunology