Divalent siRNA for prion disease
Juliana E Gentile, Taylor L Corridon, Fiona E. Serack, Dimas Echeverria, Zachary Kennedy, Corrie L. Gallant‐Behm, Matthew R. Hassler, Garth A. Kinberger, Margaret N Kelemen, Nikita G Kamath, Yuan Lian, Katherine Y. Gross, Rachael Miller, Kendrick DeSouza-Lenz, Michael Howard, , Sonia M. Vallabh
Divalent siRNA 2439-s4 lowers human PrP to 17% residual in transgenic mouse brain after one dose, and a separate mouse Prnp-targeting siRNA extends survival in prion-infected mice.
Nucleic Acids Research · Mar 19, 2026Peer-reviewedNeuroscience✦ In-depth digest