Author
Broad Institute
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Ken Y. Chan, Chin-Yen Lin, Qin Huang…·Benjamin E. Deverman
The paper describes BI-TfR1 CapX, a gene delivery vector that efficiently crosses the blood-brain barrier, transduces CNS neurons and astrocytes, and reduces Prnp mRNA with low doses.
Taylor L Corridon, Jill O’Moore, Alyssa Seerley…·Eric Vallabh Minikel
The paper measures PrP half-life in vivo and shows it limits the time to effect of PrP-lowering therapies, with implications for drug development and clinical trial design.
Juliana E Gentile, Taylor L Corridon, Fiona E. Serack…·Sonia M. Vallabh
Divalent siRNA 2439-s4 lowers human PrP to 17% residual in transgenic mouse brain after one dose, and a separate mouse Prnp-targeting siRNA extends survival in prion-infected mice.